Muscle-specific regulation of right ventricular transcriptional responses to chronic hypoxia-induced hypertrophy by the muscle ring finger-1 (MuRF1) ubiquitin ligase in mice

We recently identified a role for the muscle-specific ubiquitin ligase MuRF1 in right-sided heart failure secondary to pulmonary hypertension induced by chronic hypoxia (CH). MuRF1-/- mice exposed to CH are resistant to right ventricular (RV) dysfunction whereas MuRF1 Tg + mice exhibit impaired func...

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Veröffentlicht in:	BMC medical genetics 2018-09, Vol.19 (1), p.175-17, Article 175
Hauptverfasser:	Oakley, Robert H, Campen, Matthew J, Paffett, Michael L, Chen, Xin, Wang, Zhongjing, Parry, Traci L, Hillhouse, Carolyn, Cidlowski, John A, Willis, Monte S
Format:	Artikel
Sprache:	eng
Schlagworte:	Alternative splicing Animals Anoxia Antioxidants Cardiac arrhythmia Cardiomyocytes Cardiovascular disease Disease Models, Animal DNA microarrays DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Fatty acids Gene expression Gene Expression Profiling Gene Expression Regulation Gene Ontology Gene regulation Genetic aspects Genetic research Genomes Health aspects Heart diseases Heart failure Heart Failure - genetics Heart Failure - metabolism Heart Failure - physiopathology Homeobox Homeodomain Proteins - genetics Homeodomain Proteins - metabolism Humans Hypertrophy Hypoxia Hypoxia - genetics Hypoxia - metabolism Hypoxia - physiopathology Kinases Membrane proteins Metabolism Mice Mice, Knockout Microarray Microarray Analysis Molecular Sequence Annotation MuRF1 Muscle proteins Muscle Proteins - deficiency Muscle Proteins - genetics Musculoskeletal system Oxidoreductase Phosphorylation Promoter Regions, Genetic Promoters Proteins Pulmonary arteries Pulmonary hypertension Ribonucleic acid Right heart failure RNA Stem cells Transcription factors Transcription Factors - genetics Transcription Factors - metabolism Transcription, Genetic Tripartite Motif Proteins - deficiency Tripartite Motif Proteins - genetics Ubiquitin Ubiquitin-protein ligase Ubiquitin-Protein Ligases - deficiency Ubiquitin-Protein Ligases - genetics Ventricle Ventricular Dysfunction, Right - genetics Ventricular Dysfunction, Right - metabolism Ventricular Dysfunction, Right - physiopathology
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Zusammenfassung:	We recently identified a role for the muscle-specific ubiquitin ligase MuRF1 in right-sided heart failure secondary to pulmonary hypertension induced by chronic hypoxia (CH). MuRF1-/- mice exposed to CH are resistant to right ventricular (RV) dysfunction whereas MuRF1 Tg + mice exhibit impaired function indicative of heart failure. The present study was undertaken to understand the underlying transcriptional alterations in the RV of MuRF1-/- and MuRF1 Tg + mice. Microarray analysis was performed on RNA isolated from the RV of MuRF1-/-, MuRF1 Tg+, and wild-type control mice exposed to CH. MuRF1-/- RV differentially expressed 590 genes in response to CH. Analysis of the top 66 genes (> 2-fold or 3-fold or
ISSN:	1471-2350 1471-2350
DOI:	10.1186/s12881-018-0670-1