Efficient Functionalization of Organosulfones via Photoredox Catalysis: Direct Incorporation of α -Carbonyl Alkyl Side Chains into α -Allyl- β -Ketosulfones

A novel and efficient method for functionalizing organosulfones has been established, utilizing a visible-light-driven intermolecular radical cascade cyclization of -allyl- -ketosulfones. This process employs -Ir(ppy) as the photoredox catalyst and -carbonyl alkyl bromide as the oxidizing agent. Via this approach, the substrates experience intermolecular addition of -carbonyl alkyl radicals to the alkene bonds, initiating a sequence of C-C bond formations that culminate in the production of organosulfone derivatives. Notably, this technique features gentle reaction conditions and an exceptional compatibility with a wide array of functional groups, making it a versatile and valuable addition to the field of organic synthesis.