A case of bullous systemic lupus erythematosus: Diagnostic challenges and clinical implications

Key Clinical Message Skin involvement in systemic lupus erythematosus (SLE) is common. Bullous lesions in SLE patients are usually due to other autoimmune conditions or rarely, due to lupus itself. Bullous SLE is rare blistering disorder characterized by subepidermal blisters. We, hereby, present a case of bullous SLE in a 24‐year‐old female who responded well to systemic glucocorticoids, mycophenolate mofetil, and dapsone. Bullous systemic lupus erythematosus (SLE) is a rare blistering disorder associated with SLE, and clinicians should consider it in the differential diagnosis of bullous skin lesions in patients with established or suspected SLE.