Synthesis and antitumor activity of 5-trifluoromethyl-2,4- dihydropyrazol-3-one nucleosides

2,4-Dihydropyrazole glucosides 3a-3c were prepared and tested for their antitumor activity. The structures of these compounds were established by (1)H and (13)C-NMR spectroscopy. Glucoside 3b shows an in vitro IC(50) value of 16.4 muM against proliferation of the human promyelotic leukemia (HL60) ce...

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Veröffentlicht in:	Molecules (Basel, Switzerland) Switzerland), 2004-02, Vol.9 (3), p.109-116
Hauptverfasser:	Abdou, Ibrahim M, Saleh, Ayman M, Zohdi, Hussein F
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology antitumor agents Cancer Cell Line, Tumor Chromatography Ethanol glucopyranose Glucosides - chemical synthesis Glucosides - chemistry Glucosides - pharmacology Humans Leukemia Mice Nucleosides - chemical synthesis Nucleosides - chemistry Nucleosides - pharmacology Pyrazoles - chemical synthesis Pyrazoles - chemistry Pyrazoles - pharmacology Trifluoromethylpyrazole
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Zusammenfassung:	2,4-Dihydropyrazole glucosides 3a-3c were prepared and tested for their antitumor activity. The structures of these compounds were established by (1)H and (13)C-NMR spectroscopy. Glucoside 3b shows an in vitro IC(50) value of 16.4 muM against proliferation of the human promyelotic leukemia (HL60) cell line.
ISSN:	1420-3049 1420-3049
DOI:	10.3390/90300109