Age-associated sperm DNA methylation patterns do not directly persist trans-generationally

The impact of aging on the sperm methylome is well understood. However, the direct, subsequent impact on offspring and the role of altered sperm DNA methylation alterations in this process remain poorly understood. The well-defined impact of aging on sperm DNA methylation represents an excellent opp...

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Veröffentlicht in:	Epigenetics & chromatin 2019-12, Vol.12 (1), p.74-74, Article 74
Hauptverfasser:	Jenkins, Timothy G, James, Emma R, Aston, Kenneth I, Salas-Huetos, Albert, Pastuszak, Alexander W, Smith, Ken R, Hanson, Heidi A, Hotaling, James M, Carrell, Douglas T
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Age Aging Analysis Autism Bipolar disorder Deoxyribonucleic acid DNA DNA Methylation Elderly patients Epigenetic inheritance Epigenetics Fertility Genetic Loci Genotype & phenotype Humans Male Methylation Middle Aged Mutation Patients Schizophrenia Software packages Sperm Spermatozoa - metabolism Statistical analysis Studies
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Zusammenfassung:	The impact of aging on the sperm methylome is well understood. However, the direct, subsequent impact on offspring and the role of altered sperm DNA methylation alterations in this process remain poorly understood. The well-defined impact of aging on sperm DNA methylation represents an excellent opportunity to trace the direct, transgenerational transmission of these signals. We utilized the Illumina MethylationEPIC array to analyze the sperm of 16 patients with older (> 40 years of age) paternal grandfathers ('old grand paternal age' patients; OGPA) and 16 patients with younger (
ISSN:	1756-8935 1756-8935
DOI:	10.1186/s13072-019-0323-4