Four New Anthraquinones with Histone Deacetylase Inhibitory Activity from Ventilago denticulata Roots
Chromatographic separation of the crude extracts from the roots of led to the isolation of four new anthraquinones, ventilanones L-O ( - ), together with eight known anthraquinones ( - ). Their structures were elucidated by spectroscopic methods (UV, IR, H NMR, C NMR, and 2D NMR) and mass spectromet...
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Veröffentlicht in: | Molecules (Basel, Switzerland) Switzerland), 2022-02, Vol.27 (3), p.1088 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Chromatographic separation of the crude extracts from the roots of
led to the isolation of four new anthraquinones, ventilanones L-O (
-
), together with eight known anthraquinones (
-
). Their structures were elucidated by spectroscopic methods (UV, IR,
H NMR,
C NMR, and 2D NMR) and mass spectrometry (MS), as well as comparison of their spectroscopic data with those reported in the literature. HDACs inhibitory activity evaluation resulted that compound
exhibited moderate antiproliferative activity against HeLa and A549 cell lines but nontoxic to normal cell. Molecular docking indicated the phenolic functionality of
plays crucial interactions with class II HDAC4 enzyme. |
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ISSN: | 1420-3049 1420-3049 |
DOI: | 10.3390/molecules27031088 |