Unraveling the controversy between fasting and nonfasting lipid testing in a normal population: a systematic review and meta-analysis of 244,665 participants

The final decision to fast or not fast for routine lipid profile examination in a standard, healthy population is unclear. Whereas the United States and European protocols state that fasting for regular lipid analysis is unnecessary, the North American and Chinese guidelines still recommend fasting...

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Veröffentlicht in:Lipids in health and disease 2024-06, Vol.23 (1), p.199-12, Article 199
Hauptverfasser: Zaid, Ahmed B, Awad, Samah M, El-Abd, Mona G, Saied, Sara A, Almahdy, Shimaa K, Saied, AbdulRahman A, Elmalawany, Alshimaa M, AboShabaan, Hind S, Saleh, Helmy S
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Sprache:eng
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Zusammenfassung:The final decision to fast or not fast for routine lipid profile examination in a standard, healthy population is unclear. Whereas the United States and European protocols state that fasting for regular lipid analysis is unnecessary, the North American and Chinese guidelines still recommend fasting before routine lipid testing. This study aimed to unravel the contradiction between the different protocols of lipid profile testing worldwide and clarify the effect of diet on lipid profile testing only in a regular, healthy population. A literature search was conducted through May 2024. The analyses included studies performed from the date 2000 until now because the contradiction of guidelines for lipid profile testing appeared for the first time in this period. A planned internal validity evaluation was performed using the National Institute of Health (NIH) quality measurement tools for observational cohort, case‒control, controlled interventional, and cross-sectional studies. The data were synthesized according to RevMan 5.3. Eight studies with a total of 244,665 participants were included. The standardized mean difference in cholesterol in six studies showed significant differences in overall effect among fasting and nonfasting states (P 
ISSN:1476-511X
1476-511X
DOI:10.1186/s12944-024-02169-y