Magnetic targeting of paclitaxel-loaded poly(lactic- co -glycolic acid)-based nanoparticles for the treatment of glioblastoma

Glioblastoma (GBM) therapy is highly challenging, as the tumors are very aggressive due to infiltration into the surrounding normal brain tissue. Even a combination of the available therapeutic regimens may not debulk the tumor completely. GBM tumors are also known for recurrence, resulting in survi...

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Veröffentlicht in:	International journal of nanomedicine 2018-01, Vol.13, p.4509-4521
Hauptverfasser:	Ganipineni, Lakshmi Pallavi, Ucakar, Bernard, Joudiou, Nicolas, Bianco, John, Danhier, Pierre, Zhao, Mengnan, Bastiancich, Chiara, Gallez, Bernard, Danhier, Fabienne, Préat, Véronique
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Aqueous solutions Biomedical materials Blood-brain barrier Blood-Brain Barrier - drug effects Blood-Brain Barrier - pathology Brain cancer Brain research Cancer Cancer therapies Cancer treatment Cell division Cell Line, Tumor Chemotherapy Contrast media Diagnostic imaging Drug delivery systems EDTA Endocytosis - drug effects Female Ferric oxide Fluorescence Fluorescence microscopy Gadoterate meglumine glioblastoma Glioblastoma - drug therapy Glioblastoma - pathology Glioblastomas Gliomas Health aspects Humans Iron compounds Lactic Acid - chemistry Life Sciences magnetic targeting Magnetics Mice, Nude Microscopy nanomedicine Nanoparticles Nanoparticles - chemistry Nervous system NMR Nuclear magnetic resonance Original Research Paclitaxel - pharmacology Paclitaxel - therapeutic use Permeability Pharmaceutical sciences PLGA- based-nanoparticles Polyglycolic Acid - chemistry Polylactic Acid-Polyglycolic Acid Copolymer Polyvinyl alcohol Recurrence (Disease) Surfactants Survival Analysis Tissue Distribution - drug effects Toxicity Tumors Xenograft Model Antitumor Assays
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Zusammenfassung:	Glioblastoma (GBM) therapy is highly challenging, as the tumors are very aggressive due to infiltration into the surrounding normal brain tissue. Even a combination of the available therapeutic regimens may not debulk the tumor completely. GBM tumors are also known for recurrence, resulting in survival rates averaging
ISSN:	1178-2013 1176-9114 1178-2013
DOI:	10.2147/IJN.S165184