The addition of avibactam renders piperacillin an effective treatment for Mycobacterium abscessus infection in an in vivo model

Treating infection is challenging due to the potent β-lactamase Bla (Beta-lactamase of . Avibactam is a non-β-lactam, β-lactamase inhibitor shown to inhibit Bla . We tested whether avibactem can render piperacillin effective against . In-vitro, avibactam enhanced the activity of piperacillin by 16-32 fold, with no significant effect on meropenem. In an in-vivo model, meropenem and piperacillin/avibactam significantly decreased infection burden compared to untreated controls. Neither piperacillin nor avibactam alone had a significant effect.