Lewis acid-promoted direct synthesis of isoxazole derivatives

Lewis acid-promoted direct synthesis of isoxazole derivatives

Isoxazole derivatives were synthesized via a one-pot method utilizing 2-methylquinoline derivatives as template substrates, sodium nitrite as a nitrogen-oxygen source, and solely using aluminum trichloride as the additive. This approach circumvents the need for costly or highly toxic transition meta...

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Veröffentlicht in:Beilstein journal of organic chemistry 2023, Vol.19 (1), p.1562-1567
Hauptverfasser: Qiu, Dengxu, Jiang, Chenhui, Gao, Pan, Yuan, Yu
Format: Artikel
Sprache:eng
Schlagworte:
Acids
Aluminum
Aluminum chloride
aluminum trichloride
Chemistry
Copper
Full Research Paper
Higher education
isoxazole derivatives
lewis acid
Metals
Nitrogen
Sodium
Sodium nitrite
Transition metals
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Beschreibung
Zusammenfassung:Isoxazole derivatives were synthesized via a one-pot method utilizing 2-methylquinoline derivatives as template substrates, sodium nitrite as a nitrogen-oxygen source, and solely using aluminum trichloride as the additive. This approach circumvents the need for costly or highly toxic transition metals and presents a novel pathway for the synthesis of isoxazole derivatives.
ISSN:1860-5397
2195-951X
1860-5397
DOI:10.3762/bjoc.19.113