Elevated international normalized ratio contributes to poor prognosis in patients with traumatic lung injury

To investigate the pivotal determinants contributing to the adverse prognosis in patients afflicted with traumatic lung injury (TLI), with an aim to mitigate the elevated mortality rate associated with this condition. A retrospective analysis was carried out on 106 TLI patients who were admitted to...

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Veröffentlicht in:Frontiers in medicine 2024-08, Vol.11, p.1426999
Hauptverfasser: Lin, Qingwei, Peng, Enlan, Deng, Xingping, Song, Xiaomin, Zhong, Lincui, He, Longping, Zeng, Qingbo, Song, Jingchun
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Sprache:eng
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Zusammenfassung:To investigate the pivotal determinants contributing to the adverse prognosis in patients afflicted with traumatic lung injury (TLI), with an aim to mitigate the elevated mortality rate associated with this condition. A retrospective analysis was carried out on 106 TLI patients who were admitted to the intensive care unit of a comprehensive hospital from March 2018 to November 2022. The patients were categorized into two groups based on their 28-day outcome: the survival group (  = 88) and the death group (  = 18). Random forest model, least absolute shrinkage and selection operator (LASSO) regression and support vector machine recursive feature elimination (SVM-RFE) were utilized to pinpoint the primary factors linked to poor prognosis in TLI patients. The Receiver Operating Characteristic (ROC) curve analysis was utilized to ascertain the predictive value of INR in forecasting the prognosis of TLI patients. Based on the cut-off value of INR, patients were categorized into two groups: INR ≥ 1.36 group (  = 35) and INR 
ISSN:2296-858X
2296-858X
DOI:10.3389/fmed.2024.1426999