A retrospective study on 464 bullous pemphigoid patients in Northeast China

The data on epidemiological and clinical characteristics, auxiliary examination, complication, and treatment of BP patients were collected from the hospital. The patients aged from 14 to 97 years, with an average age of 73.14 ± 2.32 years, a male-female (M/F) ratio of 1.32:1, accounting for 0.73% (464/63,969) of dermatology inpatients which was stable per year; their average hospital stay was 24.93 ± 6.21 days; 73 (15.73%) patients had mucous membrane and 35 (7.54%) had fever. Variables Cases Percentage (%) Gender Male 264 56.9 Female 200 43.1 Recurrence 81 17.5 Misdiagnosis 24 5.2 DIF IgG or C3 (+) 384 82.8 IIF IgG or C3 (+) 363 78.2 Treatment effect Cured 114 24.6 Improved 305 65.7 Unimproved 45 9.7 Concomitant disease Neurological system 101 21.8 Circulatory system 71 15.3 Respiratory system 53 11.4 Motor system 33 7.1 Immune system 30 6.5 Urinary system 17 3.7 Digestive system 12 2.6 Blood system 7 1.5 Genital system 5 1.1 Death cause Respiratory failure 7 1.5 Circulatory failure 6 1.3 Alimentary tract hemorrhage 1 0.2 Severe infections 2 0.4 Sudden death because of unknown etiology 1 0.2 Disease severity Mild 83 17.9 Moderate 269 58.0 Severe 112 24.1 BP: Typical BP has significant pathological features, while it may present as eczematoid erythema in the early stage, leading to a misdiagnosis rate of 5.17%. [...]multiple biopsies are required for making a definite diagnosis.