Association between Preoperative Plasma sRAGE Levels and Recovery from Cardiac Surgery

Background. The receptor for advanced glycation end products (RAGE) is an inflammation-perpetuating receptor, and soluble RAGE (sRAGE) is a marker of cellular RAGE expression. This study investigated whether raised plasma levels prior to surgery of sRAGE or S100A8/A9 (a RAGE ligand) were associated...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Mediators of Inflammation 2013-01, Vol.2013 (2013), p.730-736-165
Hauptverfasser:	Creagh-Brown, Benedict C., Quinlan, Gregory J., Hector, Lauren R., Evans, Timothy W., Burke-Gaffney, Anne
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Biomarkers - metabolism Blood plasma Cardiac Surgical Procedures Cardiopulmonary Bypass Clinical Study Female Gene Expression Regulation Health aspects Heart Heart Diseases - blood Heart Diseases - surgery Humans Inflammation Length of Stay Ligands Male Middle Aged Multivariate Analysis Odds Ratio Physiological aspects Preoperative Period Prospective Studies Receptor for Advanced Glycation End Products Receptors, Immunologic - blood Risk Surgery Time Factors Treatment Outcome
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Background. The receptor for advanced glycation end products (RAGE) is an inflammation-perpetuating receptor, and soluble RAGE (sRAGE) is a marker of cellular RAGE expression. This study investigated whether raised plasma levels prior to surgery of sRAGE or S100A8/A9 (a RAGE ligand) were associated with longer duration of hospital care in patients undergoing cardiac surgery necessitating cardiopulmonary bypass. Methods. Patients (n=130) undergoing elective cardiac surgery were enrolled prospectively. Plasma sRAGE and S100A8/A9 concentrations were measured before and 2 h after surgery. Results. Preoperative plasma sRAGE increased significantly (P
ISSN:	0962-9351 1466-1861
DOI:	10.1155/2013/496031