2‑Methyltetrahydrofuran as a Solvent of Choice for Spontaneous Metathesis/Isomerization Sequence
A new protocol for ring-closing metathesis/isomerization sequence was developed. The reactions of selected dienes were performed in overheated 2-methyltetrahydrofuran at 120 °C and provided a wide range of cyclic vinyl ethers and amides with good yields and selectivities. Computational analysis sugg...
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Veröffentlicht in: | ACS omega 2019-01, Vol.4 (1), p.1831-1837 |
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Hauptverfasser: | , , , , |
Format: | Artikel |
Sprache: | eng |
Online-Zugang: | Volltext |
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Zusammenfassung: | A new protocol for ring-closing metathesis/isomerization sequence was developed. The reactions of selected dienes were performed in overheated 2-methyltetrahydrofuran at 120 °C and provided a wide range of cyclic vinyl ethers and amides with good yields and selectivities. Computational analysis suggests that the relative yield of products depends on a thermodynamically driven process on the basis of relative stabilities of isomers. |
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ISSN: | 2470-1343 2470-1343 |
DOI: | 10.1021/acsomega.8b03027 |