The CDKAL1 rs7747752-Bile Acids Interaction Increased Risk of Gestational Diabetes Mellitus: A Nested Case-Control Study

The study aimed to explore additive interactions of rs7747752 and GUDCA/DCA for GDM risk and whether the interactive effects on the risk of GDM was mediated increasing lysophosphatidylcholines (LPC) 18:0 and/or saturated fatty acid (SFA) 16:0. A 1:1 age-matched study nested in a prospective cohort o...

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Veröffentlicht in:	Frontiers in endocrinology (Lausanne) 2022-03, Vol.13, p.808956-808956
Hauptverfasser:	Wang, Hui, Li, Jing, Leng, Junhong, Li, Weiqin, Liu, Jinnan, Yan, Xiaoyan, Yu, Zhijie, Hu, Gang, Ma, Ronald C W, Fang, Zhongze, Wang, Ying, Yang, Xilin
Format:	Artikel
Sprache:	eng
Schlagworte:	Bile Acids and Salts Case-Control Studies CDKAL1 deoxycholic acid Diabetes, Gestational - epidemiology Diabetes, Gestational - genetics Endocrinology Female gestational diabetes mellitus glycoursodeoxycholic acid Humans Pregnancy Prospective Studies Risk Factors rs7747752 tRNA Methyltransferases - genetics
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Zusammenfassung:	The study aimed to explore additive interactions of rs7747752 and GUDCA/DCA for GDM risk and whether the interactive effects on the risk of GDM was mediated increasing lysophosphatidylcholines (LPC) 18:0 and/or saturated fatty acid (SFA) 16:0. A 1:1 age-matched study nested in a prospective cohort of pregnant women (207 pairs) was organized in Tianjin, China. Additive interactions were used to test interaction effects while mediation analyses and Sobel tests were used to test mediation effects of LPC18:0 and SFA16:0 between copresence of rs7747752 and low GUDCA/DCA, and GDM risk. The rs7747752 was associated with GDM (P
ISSN:	1664-2392 1664-2392
DOI:	10.3389/fendo.2022.808956