HIV-Induced Thymic Insufficiency and Aging-Related Immunosenescence on Immune Reconstitution in ART-Treated Patients

The mechanisms underlying unsatisfactory immune reconstitution in HIV-1 positive patients under ART have not been fully elucidated, even after years of investigation. Thus, this study aimed to assess the correlation between age and thymic production profile, and its influence on inadequate immunolog...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Vaccines (Basel) 2024-06, Vol.12 (6), p.612
Hauptverfasser:	Guedes, Maria Carolina Santos, Carvalho-Silva, Wlisses Henrique Veloso, Andrade-Santos, José Leandro, Brelaz-de-Castro, Maria Carolina Accioly, Souto, Fabrício Oliveira, Montenegro, Lílian Maria Lapa, Guimarães, Rafael Lima
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired immune deficiency syndrome Age Aging AIDS Analysis Antiretroviral therapy Antiviral agents CD4 antigen CD4+ T cell reconstitution CD45RA antigen Cells Communication Dosage and administration Drug therapy Evaluation Flow cytometry Health aspects HIV HIV infection Human immunodeficiency virus Immune reconstitution Immune response Immune system immunological non-responders Immunology Immunosenescence Infections Influence Lymphocytes Lymphocytes T Medical records Normal distribution Patients Recovery T cells thymic exhaustion Thymus Thymus gland
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The mechanisms underlying unsatisfactory immune reconstitution in HIV-1 positive patients under ART have not been fully elucidated, even after years of investigation. Thus, this study aimed to assess the correlation between age and thymic production profile, and its influence on inadequate immunological recovery. Here, 44 ART-treated patients with undetectable plasma HIV-1 load (
ISSN:	2076-393X 2076-393X
DOI:	10.3390/vaccines12060612