Cyclosporine A-loaded drug delivery systems inhibit scar formation after glaucoma surgery in rabbits

[5,6] It is believed that scar formation is highly active for about 3 months after surgery, and is greatest in the first month. [...]sustained delivery of drugs aimed at preventing scar formation could help regulate the wound healing process more effectively. The rabbits were housed in the animal facilities of the Eye and ENT Hospital (Fudan University) under natural light conditions with free access to food and water. Compared with the control group, there was a significant decrease in IOP in the coat group (P < 0.001) but not in the gel group (P = 0.345). [...]these results suggest that CsA significantly decreased postoperative IOP, especially when applied as a coat on the GDD, compared with the control group. The key finding of H&E staining was that there was less scar tissue in the gel and the coat groups than that in the control group, indicating that the CsA inhibited scar tissue formation in rabbit eyes. [...]the blebs were significantly larger in the gel and the coat groups than those in the control group.