Design, synthesis, spectral characterization, multiple-biological activities, docking and in silico ADMET studies of thiazolidinones

[Display omitted] •Social support from friends during adolescence predicts inflammation in adulthood.•Youth friendships are tied to higher adult inflammation for Asian & Latinx participants.•Youth friendships are linked to lower adult inflammation for White participants.•The role of support from friends may be unique for racially minoritized individuals.•Social support is modifiable and may be a lucrative intervention target to explore. A series of novel thiazolidinones (5a-5i) are synthesized and characterized by FT-IR, 1H NMR and 13C NMR spectral studies. Docking studies were carried out for the synthesised compound using the protein PDB Code 1HNY, 1VMP and 3A4A and it proved that all the synthesised compounds exhibit better binding affinity in all the above said proteins. Based on the docking results of all the newly synthesized compounds are screened for their anti-diabetic, anti-inflammatory and anti-oxidant activities. The synthesized compounds showed a very good potent activity towards anti-diabetic and anti-inflammatory properties compared with standard and exhibit moderate anti-oxidant activity than standard. Furthermore, to analysis the physiochemical and pharmacokinetic features of the compounds (5a-5i) are analysed using the SwissADME online application.