Effectiveness and tolerability of lacosamide in children with drug resistant epilepsy

Effectiveness and tolerability of lacosamide in children with drug resistant epilepsy

•The retention rate of lacosamide at 3, 12 and 24 months was 89.9%, 68.4% and 54.4%.•Somnolence, behaviour changes, headache and dizziness occured as side-effects.•Sodium channel blocker as concomitant use resulted in a higher risk of side-effects.•High number of concomitant anti-seizure medications...

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Veröffentlicht in:Epilepsy & behavior reports 2023-01, Vol.21, p.100574-100574, Article 100574
Hauptverfasser: Driessen, J.T., Wammes–van der Heijden, E.A., Verschuure, P., Fasen, K.C.F.M., Teunissen, M.W.A., Majoie, H.J.M.
Format: Artikel
Sprache:eng
Schlagworte:
Effectiveness
Lacosamide
Paediatric
Refractory Epilepsy
Side-effects
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Zusammenfassung:•The retention rate of lacosamide at 3, 12 and 24 months was 89.9%, 68.4% and 54.4%.•Somnolence, behaviour changes, headache and dizziness occured as side-effects.•Sodium channel blocker as concomitant use resulted in a higher risk of side-effects.•High number of concomitant anti-seizure medications result in continuing lacosamide. We retrospectively studied the efficacy and tolerability of lacosamide (LCM) in children with drug-resistant epilepsy in a tertiary care centre in the Netherlands, from 2013 till 2019, with a follow-up of two years. 79 children, aged 
ISSN:2589-9864
2589-9864
DOI:10.1016/j.ebr.2022.100574