Bone induction and defect repair by true bone ceramics incorporated with rhBMP-2 and Sr

Objective: To study the bone induction and defect repair of true bone ceramics (TBC) combined with rhBMP-2 and Sr. Methods: MC3T3-E1 cells were used to evaluate the bioactivity of the composite. Cell proliferation activity was detected by CCK-8, ALP activity was detected by p-nitrophenyl phosphate (...

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Veröffentlicht in:	Journal of materials science. Materials in medicine 2021-09, Vol.32 (9), p.107-107, Article 107
Hauptverfasser:	Zhang, Chunli, Xu, Gang, Han, Liwei, Hu, Xiantong, Zhao, Yantao, Li, Zhonghai
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological activity Biomaterials Biomedical Engineering and Bioengineering Biomedical materials Bone and Bones - cytology Bone and Bones - drug effects Bone and Bones - physiology Bone growth Bone morphogenetic protein 2 Bone Morphogenetic Protein 2 - chemistry Bone Morphogenetic Protein 2 - pharmacology Bone Regeneration - drug effects Bone Substitutes - chemistry Bone Substitutes - pharmacology Cell Differentiation - drug effects Cell growth Cell proliferation Cells, Cultured Ceramics Ceramics - chemistry Ceramics - pharmacology Chemistry and Materials Science Cholecystokinin Coated Materials, Biocompatible - chemistry Coated Materials, Biocompatible - pharmacology Composites Cytology Engineering Engineering, Biomedical Female Fractures, Bone - therapy Glass Male Materials Science Materials Science, Biomaterials Materials Testing Mice Mice, Inbred BALB C Mice, Nude Morphology Natural Materials Orthopaedic implants Osteogenesis Osteogenesis - drug effects p-Nitrophenylphosphate Polymer Sciences Rabbits Recombinant Proteins - chemistry Recombinant Proteins - pharmacology Regenerative Medicine/Tissue Engineering Repair Scanning electron microscopy Science & Technology Strontium - chemistry Strontium - pharmacology Surfaces and Interfaces Technology Thin Films Tissue Engineering Constructs and Cell Substrates Tissue Scaffolds - chemistry Transforming Growth Factor beta - chemistry Transforming Growth Factor beta - pharmacology
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Zusammenfassung:	Objective: To study the bone induction and defect repair of true bone ceramics (TBC) combined with rhBMP-2 and Sr. Methods: MC3T3-E1 cells were used to evaluate the bioactivity of the composite. Cell proliferation activity was detected by CCK-8, ALP activity was detected by p-nitrophenyl phosphate (PNPP), and the differences of material surface topography were observed by scanning electron microscopy (SEM). Bone induction was verified by the implantation in nude mice. The rabbit femoral condyle defect model was achieved to verify the bone defect repair ability of the material. Results: SEM results showed nearly the same surface morphology and cell proliferation quantified by CCK-8 showed that compared with TBC, both TBC&Sr and TBC&BMP-2&Sr had a significant promoting effect ( P
ISSN:	0957-4530 1573-4838
DOI:	10.1007/s10856-021-06587-7