Case report: Durable response after pembrolizumab in combination with radiation - induced abscopal effect in platinum - refractory metastatic endometrial clear cell carcinoma

Case report: Durable response after pembrolizumab in combination with radiation - induced abscopal effect in platinum - refractory metastatic endometrial clear cell carcinoma

Advanced endometrial clear cell carcinoma (CCC) tends to have poor prognosis owing to aggressive clinical behavior and poor response to conventional chemotherapy. Herein, we report a case of platinum-refractory recurrent ECCC successfully treated with the combination of pembrolizumab, localized radi...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Frontiers in immunology 2022-12, Vol.13, p.1079253
Hauptverfasser: Kao, Chien-Hsiang, Liu, Chien-Ting, Lin, Hao, Huang, Yung-Cheng, Lan, Jui, Ou, Yu-Che, Fu, Hung-Chun, Wu, Chen-Hsuan
Format: Artikel
Sprache:eng
Schlagworte:
abscopal effect
Antibodies, Monoclonal, Humanized - therapeutic use
ARID1A
Carcinoma - drug therapy
clear cell carcinoma
endometrial cancer
Female
Humans
Immunology
immunotherapy
pembrolizumab
Platinum
Uterine Neoplasms - drug therapy
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Advanced endometrial clear cell carcinoma (CCC) tends to have poor prognosis owing to aggressive clinical behavior and poor response to conventional chemotherapy. Herein, we report a case of platinum-refractory recurrent ECCC successfully treated with the combination of pembrolizumab, localized radiotherapy and a few cycles of chemotherapy with an extremely durable response even after cessation of immunotherapy for 3 years at the time of publication.
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2022.1079253