A comparison of four different models of acute respiratory distress syndrome in sheep

Acute respiratory distress syndrome (ARDS) can have various causes. The study objective was to investigate whether different pathophysiologic models of ARDS would show different respiratory, cardiovascular and inflammatory outcomes. We performed a prospective, randomized study in 27 ventilated ewes...

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Veröffentlicht in:	Respiratory research 2020-08, Vol.21 (1), p.209-209, Article 209
Hauptverfasser:	Engel, Monique, Nowacki, Relana M E, Jonker, Elly M, Ophelders, Daan, Nikiforou, Maria, Kloosterboer, Nico, Zimmermann, Luc J I, van Waardenburg, Dick A, Kramer, Boris W
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute respiratory distress syndrome Adult respiratory distress syndrome Albumins Albumins - toxicity Alveoli Animal research models Animals ARDS Biomarkers - blood Blood pressure Bronchoalveolar Lavage - adverse effects Bronchoalveolar Lavage - methods Comparative analysis Complications and side effects Cytokines Development and progression Differentiation Disease Models, Animal Edema Experiments Extra-pulmonary Female Gas exchange Histology Hydrochloric acid Hydrochloric Acid - toxicity Inflammation Inflammation Mediators - blood Infusions, Intravenous Injury prevention Interleukin 6 Interleukin 8 Interleukins Intravenous administration Lavage Leukocytes Lipopolysaccharides Lipopolysaccharides - toxicity Lung injury Lungs Markers Mechanical ventilation Ostomy Oxygenation Pathophysiology Phospholipids Prospective Studies Proteins Pulmonary Respiratory distress syndrome Respiratory Distress Syndrome - blood Respiratory Distress Syndrome - chemically induced Respiratory Distress Syndrome - pathology Sheep Surfactants Trachea Trachea - drug effects Trachea - pathology Ventilation Ventilators Wall thickness
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Beschreibung
Zusammenfassung:	Acute respiratory distress syndrome (ARDS) can have various causes. The study objective was to investigate whether different pathophysiologic models of ARDS would show different respiratory, cardiovascular and inflammatory outcomes. We performed a prospective, randomized study in 27 ventilated ewes inducing ARDS using three different techniques to mimic the pulmonary causes of ARDS (ARDSp): warm saline lavage (n = 6), intratracheal hydrochloric acid (HCl; n = 6), intratracheal albumin (n = 10), and one technique to mimic an extrapulmonary cause of ARDS (ARDSexp): intravenous lipopolysaccharide (LPS iv; n = 5). ARDS was defined when PaO was
ISSN:	1465-993X 1465-9921 1465-993X 1465-9921
DOI:	10.1186/s12931-020-01475-0