Ferroptosis: A Promising Therapeutic Target for Neonatal Hypoxic-Ischemic Brain Injury

Ferroptosis is a type of programmed cell death caused by phospholipid peroxidation that has been implicated as a mechanism in several diseases resulting from ischemic-reperfusion injury. Most recently, ferroptosis has been identified as a possible key injury mechanism in neonatal hypoxic-ischemic br...

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Veröffentlicht in:	International journal of molecular sciences 2022-07, Vol.23 (13), p.7420
Hauptverfasser:	Peeples, Eric S., Genaro-Mattos, Thiago C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Brain injury Cell death encephalopathy Enzymes Ferroptosis glutathione GPX4 Hypoxia iron free radicals Ischemia Lipid peroxidation Lipids Literature reviews Neonates Neurodegeneration neuroprotection Oxidation Oxidative stress Pathophysiology Peroxidation phospholipid peroxidation Phospholipids Physiology Reperfusion Review Therapeutic targets Traumatic brain injury
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Beschreibung
Zusammenfassung:	Ferroptosis is a type of programmed cell death caused by phospholipid peroxidation that has been implicated as a mechanism in several diseases resulting from ischemic-reperfusion injury. Most recently, ferroptosis has been identified as a possible key injury mechanism in neonatal hypoxic-ischemic brain injury (HIBI). This review summarizes the current literature regarding the different ferroptotic pathways, how they may be activated after neonatal HIBI, and which current or investigative interventions may attenuate ferroptotic cell death associated with neonatal HIBI.
ISSN:	1422-0067 1661-6596 1422-0067
DOI:	10.3390/ijms23137420