Fibrous hamartoma of infancy with pseuodoangiomatous pattern

Sections examined from the mass showed keratinized stratified squamous epithelium lined tissue showing an encapsulated triphasic organoid architecture pattern composed of mature adipocytes, intersecting fascicles of fibroblastic spindle cells and predominant collagenised areas showing prominent psuedoangiomatous pattern with occasional foci of immature mesenchymal tissue. [4] Though it is named as a hamartoma, some researchers believe that FHI should be regarded as a tumor owing to its congenital appearance in many, rare reports of coexistent sarcomatoid areas,[3] few cases of associations with tuberous sclerosis or Williams syndrome[5] and the various cytogenetic alterations reported in the recent past. Immunohistochemical analysis demonstrates reactivity for SMA in mature fibrous tissue, S100 protein in the mature adipose tissue, and variable CD34 reactivity in the pseudoangiomatous foci.