Coffee prevents fatty liver disease induced by a high-fat diet by modulating pathways of the gut-liver axis

Coffee consumption is inversely associated with the risk of non-alcoholic fatty liver disease (NAFLD). A gap in the literature still exists concerning the intestinal mechanisms that are involved in the protective effect of coffee consumption towards NAFLD. In this study, twenty-four C57BL/6J mice we...

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Veröffentlicht in:	Journal of nutritional science (Cambridge) 2019, Vol.8, p.e15-e15, Article e15
Hauptverfasser:	Vitaglione, Paola, Mazzone, Giovanna, Lembo, Vincenzo, D'Argenio, Giuseppe, Rossi, Antonella, Guido, Maria, Savoia, Marcella, Salomone, Federico, Mennella, Ilario, De Filippis, Francesca, Ercolini, Danilo, Caporaso, Nicola, Morisco, Filomena
Format:	Artikel
Sprache:	eng
Schlagworte:	acyl coenzyme A Acyl-CoA Oxidase - metabolism alanine transaminase Alanine Transaminase - blood Alcaligenaceae Animals ATP Binding Cassette Transporter 1 - metabolism ATP Binding Cassette Transporter, Subfamily G, Member 1 - metabolism Blood Glucose blood serum Caffeine Carbohydrates cecum cholesterol Cholesterol - blood Claudins - metabolism Coffee Coffee - metabolism colon decaffeination Diabetes Diet Diet, High-Fat - adverse effects Dietary Supplements duodenum energy intake energy metabolism fatty liver feces Feces - microbiology free fatty acids Gastrointestinal Microbiome - drug effects Gene expression gene expression regulation glucose Gut microbiota Gut permeability Haptoglobins - metabolism high fat diet Inflammation intestinal microorganisms Intestines - drug effects lipid metabolism Lipids liver Liver - drug effects Liver - pathology Liver diseases Male messenger RNA Metabolic Syndrome Metabolites Mice Mice, Inbred C57BL Non-alcoholic Fatty Liver Disease - prevention & control Non-alcoholic steatohepatitis Nutrition research nutrition risk assessment Obesity peptide YY Permeability peroxisome proliferator-activated receptor alpha Physiology Polyphenols Polyphenols - pharmacology PPAR alpha - metabolism protective effect Protein Precursors - metabolism RNA, Messenger - metabolism Rodents Trends
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Zusammenfassung:	Coffee consumption is inversely associated with the risk of non-alcoholic fatty liver disease (NAFLD). A gap in the literature still exists concerning the intestinal mechanisms that are involved in the protective effect of coffee consumption towards NAFLD. In this study, twenty-four C57BL/6J mice were divided into three groups each receiving a standard diet, a high-fat diet (HFD) or an HFD plus decaffeinated coffee (HFD+COFFEE) for 12 weeks. Coffee supplementation reduced HFD-induced liver macrovesicular steatosis (
ISSN:	2048-6790 2048-6790
DOI:	10.1017/jns.2019.10