Asteltoxins with Antiviral Activities from the Marine Sponge-Derived Fungus Aspergillus sp. SCSIO XWS02F40

Two new asteltoxins named asteltoxin E (2) and F (3), and a new chromone (4), together with four known compounds were isolated from a marine sponge-derived fungus, Aspergillus sp. SCSIO XWS02F40. The structures of the compounds (1-7) were determined by the extensive 1D- and 2D-NMR spectra, and HRESI...

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Veröffentlicht in:	Molecules (Basel, Switzerland) Switzerland), 2016-01, Vol.21 (1), p.E34-E34
Hauptverfasser:	Tian, Yong-Qi, Lin, Xiu-Ping, Wang, Zhen, Zhou, Xue-Feng, Qin, Xiao-Chu, Kaliyaperumal, Kumaravel, Zhang, Tian-Yu, Tu, Zheng-Chao, Liu, Yonghong
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals antiviral (H1N1 and H3N2) activity Antiviral Agents - chemistry Antiviral Agents - isolation & purification Antiviral Agents - pharmacology Aspergillus Aspergillus - metabolism asteltoxins Biological activity Fungi Influenza A Virus, H1N1 Subtype - drug effects Influenza A Virus, H3N2 Subtype - drug effects Laboratories Metabolites Microbial Sensitivity Tests Molecular Structure Porifera - microbiology Pyrones - chemistry Pyrones - isolation & purification Pyrones - pharmacology Respiratory diseases sponge-derived fungus
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Zusammenfassung:	Two new asteltoxins named asteltoxin E (2) and F (3), and a new chromone (4), together with four known compounds were isolated from a marine sponge-derived fungus, Aspergillus sp. SCSIO XWS02F40. The structures of the compounds (1-7) were determined by the extensive 1D- and 2D-NMR spectra, and HRESIMS spectrometry. All the compounds were tested for their antiviral (H1N1 and H3N2) activity. Compounds 2 and 3 showed significant activity against H3N2 with the prominent IC50 values of 6.2 ± 0.08 and 8.9 ± 0.3 μM, respectively. In addition, compound 2 also exhibited inhibitory activity against H1N1 with an IC50 value of 3.5 ± 1.3 μM.
ISSN:	1420-3049 1420-3049
DOI:	10.3390/molecules21010034