Two New Flavonol Glycosides from Polygala sibirica L. var megalopha Fr

Two New Flavonol Glycosides from Polygala sibirica L. var megalopha Fr

Two new flavonol glycosides, named polygalin H (1) and polygalin I (2), as well as the known compound polygalin D (3), were isolated from the whole plant of Polygala sibirica L. var megalopha Fr. Their structures were elucidated on the basis of spectroscopic data analysis. These flavonol glycosides...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Molecules (Basel, Switzerland) Switzerland), 2015-12, Vol.20 (12), p.21494-21500
Hauptverfasser: Huang, Yan-Jie, Zhou, Ling-Yun, Wang, Jun-Min, Li, Qiang, Geng, Yuan-Yuan, Liu, Hai-Yang, Hua, Yan
Format: Artikel
Sprache:eng
Schlagworte:
Data processing
Enzyme Inhibitors - isolation & purification
Enzyme Inhibitors - pharmacology
Flavonoids
flavonol glycosides
Flavonols - isolation & purification
Flavonols - pharmacology
Glycosides
Glycosides - isolation & purification
Hypotheses
In Vitro Techniques
inhibition of xanthine oxidase
Molecular Structure
Plant Extracts - pharmacology
Polygala
Polygala - chemistry
Polygala sibirica
Polygalaceae
Xanthine oxidase
Xanthine Oxidase - antagonists & inhibitors
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Two new flavonol glycosides, named polygalin H (1) and polygalin I (2), as well as the known compound polygalin D (3), were isolated from the whole plant of Polygala sibirica L. var megalopha Fr. Their structures were elucidated on the basis of spectroscopic data analysis. These flavonol glycosides exhibited strong inhibitory activities against xanthine oxidase in vitro. Their half-maximal inhibitory concentrations (IC50) were calculated, which were 9.48, 8.31, 16.00 μM, respectively.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules201219775