Antibacterial Plasma Coating with Aggregation‐Induced Emission Photosensitizers to Prevent Surgical Site Infections

Surgical site infections (SSI) are major post‐operative complications following surgery. Reducing SSI is a global urgency as they account for huge pecuniary, physiological, and emotional burdens for patients. Antibiotic resistance is the main challenge for surgeons dealing with SSIs. Aggregation‐induced emission photosensitisers (AIE PS) with their distinct optical characteristics, biocompatibility, low toxicity, and target specificity, hold the potential for the treatment of SSI. Herein, a synergetic strategy combining plasma polymerization and AIE PS is adopted to develop coatings that can eradicate SSI‐causing bacteria. These coatings can preferentially kill Gram‐negative and Gram‐positive bacteria over mammalian cells after triggered by light irradiation. The cell viability and immunostaining studies confirmed their biocompatibility on mammalian cells. The antibacterial mechanistic studies explored their ability to generate reactive oxygen species (ROS), which is crucial for overcoming antibiotic resistance. Thus, this study opens an avenue toward antibacterial coatings to decrease the prevalence of SSI. A synergetic strategy combining plasma technology and aggregation‐induced emission photosensitizers‐based photodynamic therapy to develop coatings that can eradicate bacterial infections.