Epigenetics and diabetes mellitus

Epigenetics and diabetes mellitus

Epigenetic mechanisms were shown to be involved in the control of endocrine cell fate decision, islet differentiation, β-cell identity, proliferation, and mature function. The pathologic mechanisms involved in the development of type 1 diabetes may include DNA methylation, histone modification, micr...

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Veröffentlicht in:The Egyptian journal of internal medicine 2016-04, Vol.28 (2), p.39-51
1. Verfasser: Rehan, Mohammed K.
Format: Artikel
Sprache:eng
Schlagworte:
diabetes
epigenetic
Epigenetics
gene expression
Internal Medicine
Medicine & Public Health
Review Article
Online-Zugang:Volltext
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Zusammenfassung:Epigenetic mechanisms were shown to be involved in the control of endocrine cell fate decision, islet differentiation, β-cell identity, proliferation, and mature function. The pathologic mechanisms involved in the development of type 1 diabetes may include DNA methylation, histone modification, microRNA, and molecular mimicry. These mechanisms may act through the regulation of gene expression.
ISSN:1110-7782
2090-9098
DOI:10.4103/1110-7782.193890