Synchronous Ameloblastic Fibro-Odontoma, Cemento-Ossifying Fibroma, and Giant Cell Granuloma: A Hybrid Lesion

Ameloblastic fibro-odontomas (AFOs), cemento-ossifying fibromas (COFs), and giant cell granulomas (GCGs) represent mixed radiolucent/radiopaque lesions found most often in the mandible [1,2,3,4,6,7]. Though there have been reported cases documenting associations of hybrid COFs and GCGs, there have been no reported cases documenting hybrid AFOs and cemento-ossifying fibromas. The following report presents a unique case of the development of an AFO in combination with a COF and a GCG in the mandible of an 8-year-old male. This combination has not yet been described in the literature, and the purpose of this case report is to highlight the presentation of and review the clinical features and treatment recommendations for this combined lesion. •AFOs, COFs, and GCGs are mixed radiolucent/radiopaque lesions found most often in the mandible.•This is the first documented case of a hybrid lesion composed of an AFO, a COF, and a GCG.•Treatment of the hybrid lesion was complete surgical resection.