Wilms Tumor-1 (WT1) rs16754 Polymorphism and Clinical Outcome in Acute Myeloid Leukemia

Cytogenetic evaluation and risk stratification are important steps in the classification of acute myeloid leukemia (AML) and also in determining the best treatment modality. Although cytogenetically normal acute myeloid leukemia (CN-AML) represents a large group of adult patients with AML (about 45% of AML patients), several mutations in some genes including FLT3, NPM1, CEBPA, and WT1 are associated with risk assessment and clinical outcome [1,2]. The WT1 gene is located on chromosome 11p13 and was detected first as a tumor-suppressor gene in Wilm’s tumor; it also has a regulatory role in normal and malignant hematopoiesis [3]. WT1 gene mutations in CN-AML were reported in about 10% of patients and its role as a sole prognostic factor is controversial [4,5,6].