Cerebrospinal Fluid Cortisol Mediates Brain-Derived Neurotrophic Factor Relationships to Mortality after Severe TBI: A Prospective Cohort Study

Cerebrospinal Fluid Cortisol Mediates Brain-Derived Neurotrophic Factor Relationships to Mortality after Severe TBI: A Prospective Cohort Study

Distinct regulatory signaling mechanisms exist between cortisol and brain derived neurotrophic factor (BDNF) that may influence secondary injury cascades associated with traumatic brain injury (TBI) and predict outcome. We investigated concurrent CSF BDNF and cortisol relationships in 117 patients s...

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Veröffentlicht in:Frontiers in molecular neuroscience 2017-03, Vol.10, p.44-44
Hauptverfasser: Munoz, Miranda J, Kumar, Raj G, Oh, Byung-Mo, Conley, Yvette P, Wang, Zhensheng, Failla, Michelle D, Wagner, Amy K
Format: Artikel
Sprache:eng
Schlagworte:
Age
Apoptosis
Autonomic nervous system
Bayesian analysis
BDNF
Biomarkers
Brain research
Brain-derived neurotrophic factor
Cerebrospinal fluid
Cohort analysis
Cortisol
Fatalities
genetics
Hormones
Mathematical models
Medical prognosis
Menopause
Mortality
Neuroscience
Neurosciences
Secretion
TBI
Traumatic brain injury
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Zusammenfassung:Distinct regulatory signaling mechanisms exist between cortisol and brain derived neurotrophic factor (BDNF) that may influence secondary injury cascades associated with traumatic brain injury (TBI) and predict outcome. We investigated concurrent CSF BDNF and cortisol relationships in 117 patients sampled days 0-6 after severe TBI while accounting for BDNF genetics and age. We also determined associations between CSF BDNF and cortisol with 6-month mortality. variants, rs6265 and rs7124442, were used to create a gene risk score (GRS) in reference to previously published hypothesized risk for mortality in "younger patients" (
ISSN:1662-5099
1662-5099
DOI:10.3389/fnmol.2017.00044