Papillary thyroid carcinoma with biomineralization: clinical and morphological features

Papillary thyroid cancer (PTCa) is the most common form of malignant tumors of this organ, covering approximately 70% in the structure of morbidity. Pathological biomineralization is often the first diagnostic sign of ultrasound of the thyroid, so the study of its morphological features is the purpose of our paper. A total of 30 PTCa samples with the signs of biomineralization and 30 PTCa samples without biomineralization were studied. The study used histological, histochemical techniques and scanning electron microscopy with X-ray diffraction. All PTCa patients who had the signs of pathological biomineralization were combined in the first group (30 people) – 27 women and 3 men (9:1). The average age of patients of the first group was 56.93±2.18 years old. The patients were diagnosed with different histological PTCa types: 22 cases of classic variant of PTCa, 3 cases of diffuse sclerotic variant, 2 cases of follicular, 2 cases of tall cell variant, and 1 case of solid variant of PTCa. Patients who had no signs of PTCa mineralization, made up the second group. 30 people – 24 women and 6 men (4:1) – were selected in to the second group. It was found out that in the first group the largest size of tumor site averaged 1.84±0.13 cm, and in the second group the rate was 1.44±0.09 cm (p