Insulin degludec and insulin glargine 300 U/mL: Which of these two insulins causes less hypoglycemia?

[...]the study of Yamabe et al. is partly in agreement with some recently published clinical trials that gave different conclusions. [...]applying the Student's t‐test for unpaired data, we observed that patients allocated to the I‐Deg group had significantly (P < 0.01) lower glycated hemoglobin values than those of the I‐G300 group (8.57 vs 8.71%), but also significantly (P < 0.01) lower fasting plasma glucose concentrations (182 vs 191 mg/dL) and self‐monitoring plasma glucose (172 vs 178 mg/dL; P < 0.05). [...]we believe that either head‐to‐head randomized controlled trials or real‐world studies need to be designed including well‐matched groups, paying special attention to potential confounding factors.