Clinical characteristics and prognosis of pediatric myelin oligodendrocyte glycoprotein antibody-associated diseases in China

Research on myelin oligodendrocyte glycoprotein antibody (MOG-Ab)-associated disease (MOGAD) among Chinese children is relatively rare. Therefore, this study aimed to explore and analyze the clinical characteristics and prognoses of Chinese children with acquired demyelinating syndromes (ADSs) who t...

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Veröffentlicht in:	BMC pediatrics 2022-11, Vol.22 (1), p.666-12, Article 666
Hauptverfasser:	Sun, Xiaoang, Liu, Meiyan, Luo, Xiaona, Yuan, Fang, Wang, Chunmei, Wang, Simei, Xu, Quanmei, Zhang, Yuanfeng, Chen, Yucai
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired demyelinating syndromes Antibodies Autoantibodies Children China Clinical features Demyelinating diseases Disease Encephalitis Glycoproteins Health aspects Hospitals Humans Laboratories Magnetic resonance imaging Medical prognosis Multiple sclerosis Myelin oligodendrocyte glycoprotein antibody Myelin-Oligodendrocyte Glycoprotein Oligodendroglia Pediatric research Pediatrics Physiological aspects Prognosis Proteins Retrospective Studies Spinal cord Syndrome Vaccines
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Zusammenfassung:	Research on myelin oligodendrocyte glycoprotein antibody (MOG-Ab)-associated disease (MOGAD) among Chinese children is relatively rare. Therefore, this study aimed to explore and analyze the clinical characteristics and prognoses of Chinese children with acquired demyelinating syndromes (ADSs) who tested positive or negative for MOG-Ab. The clinical data of children with MOGAD who were treated in the Department of Neurology at Shanghai Children's Hospital from January 2017 to October 2021 were retrospectively collected. Among 90 children with ADSs, 30 were MOG-Ab-positive, and 60 were MOG-Ab-negative. MOG-Ab-positive children experienced more prodromal infections than did MOG-Ab-negative children (P
ISSN:	1471-2431 1471-2431
DOI:	10.1186/s12887-022-03679-3