Vitamin E Derivative Alpha-Tocotrienol Failed to Show Neuroprotective Effects after Embolic Stroke in Rats
Objective(s)Previous studies have demonstrated that pretreatment with alpha-tocotrienol (α-TCT) can reduce ischemic damage in mice following middle cerebral artery (MCA) occlusion. It is also reported to decrease stroke-dependent brain tissue damage in 12-Lox-deficient mice and spontaneously hyperte...
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| Veröffentlicht in: | Iranian journal of basic medical sciences 2009-03, Vol.12 (41) |
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| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
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| Online-Zugang: | Volltext |
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| Zusammenfassung: | Objective(s)Previous studies have demonstrated that pretreatment with alpha-tocotrienol (α-TCT) can reduce ischemic damage in mice following middle cerebral artery (MCA) occlusion. It is also reported to decrease stroke-dependent brain tissue damage in 12-Lox-deficient mice and spontaneously hypertensive rats. In the present study, the neuroprotective effects of α-TCT and rosiglitazone (RGZ) at 3 hr after cerebral ischemia were investigated. Materials and MethodsStroke was induced by embolizing a preformed clot into the MCA. Rats were assigned to vehicle, α-TCT (1 or 10 mg/kg), RGZ and sham-operation. ResultsCompared to the control group, only RGZ decreased infarct volume (P |
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| ISSN: | 2008-3866 2008-3874 |