In vivo noninvasive study of diabetic peripheral neuropathy plantar morphology and mechanical properties based on ultrasound

[...]the high cost of treatment and rehabilitation care also causes huge economic pressure on patients. [...]it is particularly important to identify, diagnose, and prevent DPN in the early or ultra-early stage. [...]it is necessary to explore the influence of DPN on the thickness and mechanical modulus of plantar soft tissue from a full plantar and multi-level perspective. The details of measurement methods of the thickness distribution and Young's modulus of eight soft tissue sites are shown in Supplementary Materials, http://links.lww.com/CM9/B779 for the experimental equipment and methods and Supplementary Figure 1, http://links.lww.com/CM9/B779. Age had a significant impact on Young's modulus of the MIC and MAC of soft tissue in the soles of healthy subjects (P