Palladium-Mediated Hydroamination of DNA-Conjugated Aryl Alkenes

Palladium-Mediated Hydroamination of DNA-Conjugated Aryl Alkenes

C-N bond formation is one of the most commonly used reactions in medicinal chemistry. Herein, we report an efficient Pd-promoted hydroamination reaction between DNA-conjugated aryl alkenes and a wide scope of aliphatic amines. The described reactions are demonstrated in good to excellent conversions...

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Veröffentlicht in:Frontiers in chemistry 2022-04, Vol.10, p.851674-851674
Hauptverfasser: Cai, Kunliang, Ran, Yuzhao, Sun, Wenbo, Gao, Sen, Li, Jin, Wan, Jinqiao, Liu, Guansai
Format: Artikel
Sprache:eng
Schlagworte:
C-N bond formation
Chemistry
DNA-conjugated aryl ethylene
DNA-encoded library
hydroamination
palladium catalysis
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Zusammenfassung:C-N bond formation is one of the most commonly used reactions in medicinal chemistry. Herein, we report an efficient Pd-promoted hydroamination reaction between DNA-conjugated aryl alkenes and a wide scope of aliphatic amines. The described reactions are demonstrated in good to excellent conversions to furnish C (sp )-N bonds on DNA. This DNA-compatible transformation has strong potentials for the application into DNA-encoded library synthesis.
ISSN:2296-2646
2296-2646
DOI:10.3389/fchem.2022.851674