Observation on the therapeutic effect of probiotics on early oral feeding in the treatment of severe acute pancreatitis

ObjectivesTo evaluate the clinical efficacy of probiotics and early oral feeding in patients with severe acute pancreatitis.MethodsA prospective, randomized, controlled trial was conducted involving 66 patients, who were randomly divided into a control group (n = 32) receiving standard enteral nutri...

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Veröffentlicht in:Frontiers in medicine 2024-12, Vol.11
Hauptverfasser: Yanan Zhao, Rui Zhang, Shuling Wang, Chunchun Yang, Yang Wang, Hongyun Fan, Mingyue Yang
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Sprache:eng
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Zusammenfassung:ObjectivesTo evaluate the clinical efficacy of probiotics and early oral feeding in patients with severe acute pancreatitis.MethodsA prospective, randomized, controlled trial was conducted involving 66 patients, who were randomly divided into a control group (n = 32) receiving standard enteral nutrition and an observation group (n = 34) receiving additional Bifidobacterium quadruplex live bacterial tablets. Serum inflammatory markers, including white blood cells (WBC), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and C-reactive protein (CRP), were measured on days 1, 3, and 7 post-admission. Abdominal pain scores, the computed tomography severity index (CTSI), and the Bedside Index for Severity in Acute Pancreatitis (BISAP) scores were also assessed. Additionally, defecation time and the total duration of hospitalization were compared between the two groups.ResultsInflammatory markers declined in all groups by the third day post-admission, with the observation group exhibiting a significantly greater reduction compared to the control group (p 
ISSN:2296-858X
DOI:10.3389/fmed.2024.1492108