Comparison of Pre-Operative and Post-Operative Thiol-Disulfide Levels in Acute Abdomen Patients

Aim: To evaluate role of thiol and disulfide homeostasis, a novel marker of oxidative stress, in the follow-up acute abdomen. Material and Method: This prospective study included 107 patients (62 men and 45 women) with a diagnosis of acute abdomen (AA). In all patients, age, gender and cause of acute abdomen were recorded. In addition, native thiol (-SH), total thiol (tSH) and disulfide (-S-S-) levels at baseline, admission and on postoperative day 3 were prospectively recorded and -SS-/-SH, -S-S-/tH and -SH/tSH ratios were calculated. Results: When the causes of acute abdomen were assessed, it was seen that 72 patients (67.29%) underwent surgery due to appendicitis while 5 patients (4.67%) due to lower GIS perforation, 7 patients (6.54%) due to perforated peptic ulcer, 5 patients (4.67%) due to sigmoid volvulus, 4 patients (3.74%) due to strangulated hernia and 14 patients (13.08%) due to miscellaneous reasons. When thiol and disulfide levels were assessed as a single parameter, mean thiol level was 316.71±78.16 (327.5) at preoperative period and 264.00±72.85 (278.30) at postoperative period. The mean thiol level was significantly decreased at postoperative period (p Amaç: Akut karın takibinde yeni bir oksidatif stres belirteci olan tiyol ve disülfit homeostazının rolünü araştırmak. Gereç ve Yöntem: Bu çalışma prospektif olarak planlanmıştır. Bu çalışmaya akut karın(AK) tanılı 107 (62 erkek ve 45 kadın) hasta dahil edildi.107 hastanın yaşı, cinsiyeti, akut karın sebepleri, pre-operatif yatış anındaki ve post-operatif 3. gündeki native thiol (-SH), total thiol (tSH) ve disülfit (-S-S-) seviyeleri prospektif olarak kaydedilmiş ve –SS-/-SH, -S-S -/tSH, -SH/tSH oranları hesaplanmıştır Bulgular: Akut karına neden olan sebepler incelendiğinde 72 hasta (67,29%) apandisit, 5 hasta (4,67%) alt GIS perforasyonu, 7 hasta (6,54%) peptik ulcus perforasyonu, 5 hasta (4,67%) sigmoid volvulus, 4 hasta (3,74%) strangüle herni, 14 hasta ise (13,08%) diğer nedenlerden opere olmuştu. Hastaların thiol ve disülfit seviyeleri tek parametre olarak incelendiğinde pre-operatif dönemde thiol düzeyi ortalaması 316,71±78,16 (327,5) iken post-operatif dönemde ortalama 264,00±72,85 (278,30) olarak hesaplandı, istatistiki anlamlı farklılık gösterecek şekilde post-operatif dönemde azalma saptandı (p