Urinary biomarkers of overactive bladder

[...]Kim et al[6] revealed that the levels of urinary NGF in patients with OAB were significantly higher than those in controls, although Cr value was not adjusted to urine concentration in their study. [...]significant increases in urinary NGF/Cr levels were observed between patients with wet and dry OAB by Liu et al,[4,7] suggesting that urinary NGF/Cr levels are positively related to OAB severity. According to our results, the sensitivity and specificity can reach 93.3% and 64.0%, respectively, with a cutoff value of 26.32 pg/mg. After analysis of urinary BDNF/Cr and NGF/Cr levels in 37 patients with OAB, Antunes-Lopes et al[2] found that, compared to controls, 12 patients had increased BDNF/Cr and NGF/Cr levels, 14 patients had only increased BDNF/Cr levels, 2 patients had only increased NGF/Cr levels, and nine patients showed no increased biomarkers. [...]they suggested that different phenotypic patients with OAB might have different pathophysiologic mechanisms. [...]we did not assess the value of these biomarkers after standard treatment for therapeutic assessment.