Ethanol extract of Nigella sativa has antioxidant and ameliorative effect against nickel chloride-induced hepato-renal injury in rats

Background Nickel exposure causes hepato-renal toxicity via oxidative stress. Medicinal plants with antioxidants properties are being explored as treatment options. In this study, the effect of ethanol extract of Nigella sativa (ENS) on nickel chloride (NiCl 2 )-induced hepato-renal damage was evalu...

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Veröffentlicht in:	Clinical Phytoscience 2020-09, Vol.6 (1), p.1-12, Article 64
Hauptverfasser:	Akinwumi, Kazeem Akinyinka, Jubril, Afusat Jagun, Olaniyan, Oreoluwa Oluwafunke, Umar, Yusuf Yusuf
Format:	Artikel
Sprache:	eng
Schlagworte:	Antioxidants Antioxidants (Nutrients) Aspartate Aspartate aminotransferase Biomarkers Chloride Chloride ions Comparative analysis Creatinine Damage assessment Diabetes Ethanol Gallic acid Gastroenterology Glutathione Glutathione transferase Gynecology Herbal medicine High performance liquid chromatography Kidneys Liquid chromatography Liver and kidney Malondialdehyde Medicinal plants Medicine Medicine & Public Health Nickel Nickel (Metal) Nickel chloride Nigella sativa Organs Original Contribution Oxidative stress Pediatrics Pneumology/Respiratory System Quercetin Toxicity
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Zusammenfassung:	Background Nickel exposure causes hepato-renal toxicity via oxidative stress. Medicinal plants with antioxidants properties are being explored as treatment options. In this study, the effect of ethanol extract of Nigella sativa (ENS) on nickel chloride (NiCl 2 )-induced hepato-renal damage was evaluated by monitoring biochemical and oxidative stress markers. Additionally, the antioxidant capacity and phytochemical constituents of ENS were quantified using HPLC and GC-MS. Result NiCl 2 significantly increased ( p
ISSN:	2199-1197 2199-1197
DOI:	10.1186/s40816-020-00205-9