Intestinal Microbiota and Sclerosis Lateral Amyotrophic

The human gastrointestinal tract contains numerous microorganisms. This intestinal microbiota (IM) has a mutualistic relationship with the human organism, and it plays a fundamental role in regulating metabolic, endocrine, and immunological functions. Intestinal dysbiosis is associated with phenotyp...

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Veröffentlicht in:Revista Ciências em Saúde 2022-03, Vol.12 (1), p.3-13
Hauptverfasser: Vilar, Mariana Dantas de Carvalho, Vale, Sancha Helena de Lima, Rosado, Eliane Lopes, Dourado Júnior, Mário Emílio Teixeira, Brandão-Neto, José, Leite-Lais, Lúcia
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Sprache:eng
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Zusammenfassung:The human gastrointestinal tract contains numerous microorganisms. This intestinal microbiota (IM) has a mutualistic relationship with the human organism, and it plays a fundamental role in regulating metabolic, endocrine, and immunological functions. Intestinal dysbiosis is associated with phenotypes of many chronic and inflammatory diseases. This association is explained by the functions of the IM and the existing bi-directional communication of the microbiota-intestine-brain axis. Studies have uncovered new evidence between the IM and neurodegenerative diseases recently, including amyotrophic lateral sclerosis (ALS). Given this, the present narrative review discusses didactically about IM, its functions, its relationship with the neuroimmune-endocrine system, and its association with neurodegenerative diseases, with emphasis on ALS.
ISSN:2236-3785
2236-3785
DOI:10.21876/rcshci.v12i1.1223