Immunohistochemical expression of androgen receptor and prostate-specific antigen in breast cancer

Immunohistochemical expression of androgen receptor and prostate-specific antigen in breast cancer

AR (androgen receptor) and PSA (prostate-specific antigen) are involved in the pathogenesis of breast cancer, but their role is not clearly defined. The purpose of this study was to analyze by immunohistochemistry the AR and PSA (prostate-specific antigen) expression in 156 female breast carcinomas...

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Veröffentlicht in:Folia histochemica et cytobiologica 2006-01, Vol.44 (3), p.165-172
Hauptverfasser: Narita, Diana, Raica, Marius, Suciu, Cristian, Cîmpean, Anca, Anghel, Andrei
Format: Artikel
Sprache:eng
Schlagworte:
Breast Neoplasms - metabolism
Female
Humans
Immunohistochemistry - methods
Prostate-Specific Antigen - metabolism
Receptor, ErbB-2 - metabolism
Receptors, Androgen - metabolism
Receptors, Estrogen - metabolism
Receptors, Progesterone - metabolism
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Zusammenfassung:AR (androgen receptor) and PSA (prostate-specific antigen) are involved in the pathogenesis of breast cancer, but their role is not clearly defined. The purpose of this study was to analyze by immunohistochemistry the AR and PSA (prostate-specific antigen) expression in 156 female breast carcinomas and to correlate the results with some histopathological parameters, like ER (estrogen receptor), PR (progesterone receptor), HER2/neu, nodal and metastasis status, histological type and grade. ARs and PSA were expressed in 112/156 (72%) and respectively in 61/156 (39%) of cases and we found a positive correlation between AR and PSA expression in breast carcinomas (p
ISSN:0239-8508
1897-5631
DOI:10.5603/4563