Effect of melatonin on duration of delirium in organophosphorus compound poisoning patients: A double-blind randomised placebo controlled trial

Effect of melatonin on duration of delirium in organophosphorus compound poisoning patients: A double-blind randomised placebo controlled trial

Background and Aims: Organophosphate compound poisoning (OPCP) is associated with high incidence of delirium. Melatonin has been tried in the treatment of delirium and has shown a beneficial effect in OPCP. This study was conducted to know the effect of melatonin on duration of delirium and recovery...

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Veröffentlicht in:Indian journal of anaesthesia 2016-11, Vol.60 (11), p.814-820
Hauptverfasser: Vijayakumar, H, Ramya, K, Duggappa, Devika, Veeranna Gowda, K, Sudheesh, K, Nethra, S, Raghavendra Rao, R
Format: Artikel
Sprache:eng
Schlagworte:
Anesthesia
Blood pressure
Care and treatment
Conflicts of interest
Consciousness
Delirium
Drug dosages
Health aspects
Heart rate
Intensive care
Lipid peroxidation
Melatonin
Mortality
organophosphorus compound poisoning
Original
Oxidative stress
Patients
Poisoning
Quality
sedation
Sleep
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Zusammenfassung:Background and Aims: Organophosphate compound poisoning (OPCP) is associated with high incidence of delirium. Melatonin has been tried in the treatment of delirium and has shown a beneficial effect in OPCP. This study was conducted to know the effect of melatonin on duration of delirium and recovery profile in OPCP patients. Methods: Double-blind randomised placebo control trial in which 56 patients of OPCP confirmed by history and syndrome of OPCP with low plasma pseudocholinesterase, aged >18 years and weighing between 50 and 100 kg, and Acute Physiology and Chronic Health Evaluation II score of
ISSN:0019-5049
0976-2817
DOI:10.4103/0019-5049.193664