Asymptomatic hyperuricemia and coronary flow reserve in patients with metabolic syndrome

Asymptomatic hyperuricemia and coronary flow reserve in patients with metabolic syndrome

Patients with metabolic syndrome (MetS) are at increased risk of asymptomatic hyperuricemia (i.e., elevated serum uric acid (SUA) level without gout) and cardiovascular disease. We conducted a cross-sectional study to examine associations between SUA levels and coronary flow reserve and urate deposi...

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Veröffentlicht in:BMC rheumatology 2018-01, Vol.2 (1), p.17-17, Article 17
Hauptverfasser: Kim, Seoyoung C, Di Carli, Marcelo F, Garg, Rajesh K, Vanni, Kathleen, Wang, Penny, Wohlfahrt, Alyssa, Yu, Zhi, Lu, Fengxin, Campos, Anarosa, Bibbo, Courtney F, Smith, Stacy, Solomon, Daniel H
Format: Artikel
Sprache:eng
Schlagworte:
Asymptomatic
Biobanks
Body mass index
Cardiovascular disease
Coronary blood flow
Coronary vessels
Creatinine
DECT
Diabetes
Family medical history
Fasting
Inflammation
Insulin resistance
Ischemia
Laboratories
Medical records
Metabolic syndrome
Patients
PET/CT
Regression analysis
Rheumatism
Software
Tomography
Uric acid
Variables
Women
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Zusammenfassung:Patients with metabolic syndrome (MetS) are at increased risk of asymptomatic hyperuricemia (i.e., elevated serum uric acid (SUA) level without gout) and cardiovascular disease. We conducted a cross-sectional study to examine associations between SUA levels and coronary flow reserve and urate deposits in carotid arteries in patients with asymptomatic hyperuricemia and MetS. Adults aged ≥40 years with MetS and SUA levels ≥6.5 mg/dl, but no gout, were eligible. Using a stress myocardial perfusion positron emission tomography (PET), we assessed myocardial blood flow (MBF) at rest and stress and calculated coronary flow reserve (CFR). CFR
ISSN:2520-1026
2520-1026
DOI:10.1186/s41927-018-0027-6