Prophylaxis of Invasive Fungal Infection in Neonates: A Narrative Review for Practical Purposes

is the most frequent cause of invasive fungal disease in preterm and/or low birth weight neonates, followed by , whilst infections from other species are rare. Considering the severity of the disease, associated with poor clinical signs and diagnostic difficulties, primary prophylaxis becomes relevant. This paper summarizes the pathogenesis and clinical presentation of invasive candidiasis in neonates, focusing on prophylaxis. For late onset invasive disease, e.g., those occurring after the 3rd (or 7th according to some definitions) day of life possible approaches are the use of fluconazole, recommended in case of weight