Waist-to-calf circumference ratio as a potential indicator of diabetes risk: results from the Longevity Check-Up (Lookup) 8

Diabetes is a prevalent metabolic condition with substantial health and economic impacts. Therefore, effective and accessible indicators are essential for early detection and prevention. This study investigates the link between the waist-to-calf circumference ratio (WCR) and diabetes risk in a large cohort from the Longevity Check-Up (Lookup) 8+ Study. The present investigation is a retrospective cross-sectional study. Diabetes was defined either as self-reported diagnosis, or fasting plasma glucose equal to or greater than 126 mg/dL, or random plasma glucose equal to or greater than 200 mg/dL. The WCR was calculated by dividing waist circumference by calf circumference. A total population of 8900 participants (mean age 57.1 ± 14.8 years, 55% women) was included in the study. The prevalence of diabetes was 9.4%. Mean WCR displayed a significant trend (p for trend