Adaptive and innate immune pathogenesis of bullous pemphigoid: A review

Bullous pemphigoid (BP) is an autoimmune blistering disease that primarily affects elderly individuals. The presentation of BP is heterogeneous, typically manifesting as microscopic subepidermal separation with a mixed inflammatory infiltrate. The mechanism of pemphigoid development is unclear. B ce...

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Veröffentlicht in:Frontiers in immunology 2023-03, Vol.14, p.1144429-1144429
Hauptverfasser: Yan, Tianmeng, Zhang, Zhenying
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Sprache:eng
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Zusammenfassung:Bullous pemphigoid (BP) is an autoimmune blistering disease that primarily affects elderly individuals. The presentation of BP is heterogeneous, typically manifesting as microscopic subepidermal separation with a mixed inflammatory infiltrate. The mechanism of pemphigoid development is unclear. B cells play a major role in pathogenic autoantibody production, and T cells, type II inflammatory cytokines, eosinophils, mast cells, neutrophils, and keratinocytes are also implicated in the pathogenesis of BP. Here, we review the roles of and crosstalk between innate and adaptive immune cells in BP.
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2023.1144429