The effects of resveratrol in animal models of primary osteoporosis: a systematic review and meta-analysis

The effects of resveratrol in animal models of primary osteoporosis: a systematic review and meta-analysis

There is still a lack of sufficient evidence-based medical data on the effect of resveratrol (Res) on primary osteoporosis (OP). This meta-analysis aimed to comprehensively evaluate the role of Res in animal models of primary OP. The PubMed, Cochrane Library, Web of Science and Embase databases were...

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Veröffentlicht in:Journal of orthopaedic surgery and research 2024-02, Vol.19 (1), p.137-137, Article 137
Hauptverfasser: An, Rongxian, Luo, Qian, Li, Lei, Cui, Dinglu, Jin, Jingchun
Format: Artikel
Sprache:eng
Schlagworte:
Acid phosphatase (tartrate-resistant)
Alkaline Phosphatase
Animal models
Animals
Bias
Bone Density
Bone mineral density
Bone turnover
Cancellous bone
Collagen
Collagen (type I)
Comparative analysis
Denosumab
Drugs
Humans
Medical advice systems
Meta-analysis
Models, Animal
Osteoporosis
Osteoporosis - diagnostic imaging
Osteoporosis - drug therapy
Osteoprotegerin
Patient compliance
Phosphatase
Phosphatases
Primary osteoporosis
Resveratrol
Sensitivity analysis
Statistical analysis
Systematic Review
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Zusammenfassung:There is still a lack of sufficient evidence-based medical data on the effect of resveratrol (Res) on primary osteoporosis (OP). This meta-analysis aimed to comprehensively evaluate the role of Res in animal models of primary OP. The PubMed, Cochrane Library, Web of Science and Embase databases were searched up to August 2023. The risk of bias was assessed by the SYRCLE RoB tool. Random- or fixed-effects models were used to determine the 90% confidence interval (CI) or standardized mean difference (SMD). Statistical analysis was performed with RevMan 5.4 and Stata 14.0. A total of 24 studies containing 714 individuals were included. Compared with those in the control group, the bone mineral density (BMD) (P 
ISSN:1749-799X
1749-799X
DOI:10.1186/s13018-024-04595-1